“The Hole” is home to around 35600 people across 22000 square miles (about the size of Tasmania or Croatia). For comparison, Wyoming as a whole has 6 people per square mile. The largest city is Belle Fourche at around 5600 people, and it is actually by far the largest city (the next biggest, Baker Montana, is less than half that size).
“The Hole” is probably the largest contiguous block of land in the lower 50 U.S. states (that forms a convex shape rather than blobbing around cities and towns) to reach such a low population density. Crucially, the entire area lies beyond the Frontier Line. In the 1890 census, the frontier was declared closed because there was no longer a line beyond which the population density dropped below 2 people per square mile. While that is still true on a state-wide scale, the emptying out of the prairie has opened up large swathes of territory like The Hole, in which conditions are what the 1890 census would have considered an untamed frontier land.